Chronic inflammation is associated with several neurological disorders. Certain mushrooms, such as turkey tail (Trametes versicolor), have compounds with anti-inflammatory effects. By reducing inflammation, these mushrooms may help protect the brain from damage and support cognitive function.

Certain mushrooms, such as maitake (Grifola frondosa), are being researched for their potential benefits on metabolic health. Conditions like diabetes and obesity can impact cognitive function, and supporting metabolic health may indirectly benefit the brain.

While not present in high amounts, some mushrooms may contain compounds associated with nootropic effects, which may enhance cognitive function, memory, and learning.